The Role of Endothelial Factors and Interleukins in the Formation of Various Degrees of Severity of the Infl ammatory Process in Children with Focal, Segmental and Lobar Pneumonia

Purpose. To reveal the role of interleukins and endothelial factors in the formation of various
degrees of severity of the infl ammatory process in children with acute pneumonia.
Materials and methods. 100 patients with acute pneumonia with (n=70) and without (n=30)
endothelial dysfunction were examined. We analyzed the indicators that characterize the production
of IL-1β, TNF-α and the state of endothelium-dependent vascular dilation in children with acute
pneumonia.
Results. It was found that children with acute pneumonia with endothelial dysfunction had
signifi cantly higher cytokine levels than children without endothelial dysfunction (p<0.001). Clinical analysis showed that focal pneumonia prevailed in patients without endothelial dysfunction, and segmental and lobar pneumonia prevailed in patients with endothelial dysfunction. Conclusions. The obtained data indicate the reduced compensatory reactions of systemic blood fl ow in the lung tissue in patients with reduced endothelium-dependent vasodilation. The regularities revealed in the work that characterize the degree of cytokine level increase and decrease of endothelium-dependent vascular dilatation can be used to predict the course of acute pneumonia.